binding of the antitumor drug adriamycin to dna-histone complexes

نویسندگان

azra rabbani from the institute of biochemistry and biophysics, tehran university of medical sciences, tehran, islamic republic of iran.

marzieh hagsharifia tagavi

bahram goliaei

چکیده

isotherms of the binding of the anthracyciine antibiotic, adriamycin (adriblastin), to dna histone complexes was studied by means of spectroscopic analysis. the results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with dna, (b) binding of the drug to dna did not change the binding affinity of histone to dna and, (c) in the explored binding range of r

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BINDING OF THE ANTITUMOR DRUG ADRIAMYCIN TO DNA-HISTONE COMPLEXES

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۶، شماره ۴، صفحات ۲۷۵-۲۷۹

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